How Many People Work at Denali Therapeutics? Headcount and Employee Trends

Denali Therapeutics, a biotechnology company focused on developing therapies for neurodegenerative diseases, employs approximately 414 people worldwide. Recent staffing data shows 67 new hires alongside 17 departures, signaling ongoing growth and measured turnover. The organization’s workforce mix reflects the scientific, clinical, and operational capabilities required to advance its drug-development pipeline.

Engineering is the largest department with 172 employees, accounting for roughly two-fifths of total headcount and underscoring the company’s emphasis on research and development. Business Management (54) and Healthcare functions (43) provide key commercial and clinical expertise, while Operations (36) and Finance & Administration (24) support day-to-day execution. Smaller yet essential groups include Sales & Support (14), Information Technology (12), Human Resources (12), and Quality (10). An additional 37 employees are classified under Other specialty roles, illustrating a diverse talent base across 10 functional areas.

San Francisco serves as Denali Therapeutics’ primary talent hub, with 289 employees—about seven in ten of the company’s workforce—based near its headquarters. The firm also maintains smaller U.S. teams in Salt Lake City (13), Chicago (5), Boston (5), Los Angeles (3), Seattle (2), New York (2), and Philadelphia (2). Internationally, Zurich hosts 5 employees, providing a foothold in Europe. A further 88 staff members work remotely or from various other locations, highlighting a flexible, distributed staffing model.