Company Insights
Published on
July 11, 2025

How Many People Work at Denali Therapeutics? Headcount and Employee Trends

Total Employees
414
7.2% from last year
23
New Hires (YTD)
73
5% of total workforce
Departments
17
650 in Engineering
Locations
19
5,012 in New York, NY

Denali Therapeutics, a biotechnology company focused on neurodegenerative diseases, employs 414 people worldwide. Recent staffing activity shows 73 incoming hires and 23 departures, indicating steady growth and controlled turnover. With nearly one-fifth of the workforce added in the most recent hiring cycle, the company continues to scale research, clinical, and operational capabilities while maintaining a balanced employee base.

Denali Therapeutics Headcount Breakdown by Department

Engineering is Denali Therapeutics’ largest team at 172 employees, representing roughly 42 % of total headcount and underscoring the company’s emphasis on scientific and technical innovation. Business Management (54) and Healthcare roles (43) form the next-largest groups, providing commercial and clinical expertise. Core operational support is distributed across Operations (36), Finance & Administration (24), and Sales & Support (14), while Human Resources and Information Technology each account for 12 employees. A diverse set of additional functions, including a small Banking & Wealth Management group and other specialized roles, round out the remaining 47 positions.

Engineering
172
Business Management
54
Healthcare
43
Operations
36
Finance and Administration
24
Sales and Support
14
Human Resources
12
Information Technology
12
Quality
10
Other
37

Denali Therapeutics Employees by Location

Headquarters-related roles are concentrated in the Bay Area, with 183 employees in San Francisco and 63 in South San Francisco. Additional California hubs include San Mateo (9), Los Angeles (3), and San Jose (6), illustrating the firm’s strong West Coast presence. Outside California, the company maintains teams in Salt Lake City (13), Boston (5), Chicago (5), and Zurich (5), enabling access to varied talent pools and research ecosystems. A further 122 employees work remotely or at other smaller sites, giving Denali Therapeutics a flexible and geographically diverse footprint.

San Francisco, CA
183
South San Francisco, CA
63
San Mateo, CA
9
Salt Lake City, UT
13
Los Angeles, CA
3
San Jose, CA
6
Boston, MA
5
Chicago, IL
5
Zurich, Switzerland
5
Other
122
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