How Many People Work at Denali Therapeutics? Headcount and Employee Trends

Denali Therapeutics is a biotechnology company with a team of 414 employees. The organization reports 48 new hires and 12 departures in the dataset, reflecting a net increase in headcount. Its workforce spans scientific, engineering, and business functions that support research, development, and commercialization activities.

Engineering is the largest function with 172 employees (about 42% of the workforce), indicating a substantial emphasis on building and scaling core platforms and capabilities. Business Management (54) and Healthcare (43) are the next largest groups, followed by Operations (36) and Finance and Administration (24). Additional functions include Sales and Support (14), Information Technology (12), Human Resources (12), and Quality (10), with 37 employees categorized as Other. The mix shows a technology- and science-heavy organization supported by key business and operations teams.

Headcount is concentrated in the Bay Area, led by San Francisco with 183 employees (about 44%) and South San Francisco with 63 (about 15%). Additional presence spans Salt Lake City (13), San Mateo (9), Fremont (7), Oakland (6), San Jose (6), Boston (5), and Chicago (5), with 117 employees grouped under Other locations. In total, the company’s footprint covers 24 locations, with roughly two-thirds of employees based in or around the San Francisco Bay Area.